Nuclear Envelope Epigenetics 1 Nuclear Envelope Influences On Genome Organization

General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Abbreviations used: nuclear envelope (NE), nuclear envelope transmembrane protein (NET), inner nuclear membrane (INM), lamin B-receptor (LBR), lamina-associated polypeptide 2 (LAP2). Abstract The nuclear periphery is a specialized environment in the nucleus that contributes to genome organization and correspondingly to gene regulation. Mammalian chromosomes and certain genes occupy defined positions within the nucleus that are heritable and tissue-specific. Genes located at the nuclear periphery tend to be inactive and this negative regulation can be reversed when they are released from the periphery in certain differentiation systems. Recent work using specially designed systems has shown that genes can be artificially tethered to the nuclear periphery by an affinity mechanism. The next important step will be to identify the endogenous nuclear envelope and chromatin proteins that participate in affinity-driven nuclear envelope tethering and determine how they are regulated.